KMID : 0931320170170010083
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´ëÇÑ»óºÎÀ§Àå°ü.Ç︮ÄÚ¹ÚÅÍÇÐȸÁö 2017 Volume.17 No. 1 p.83 ~ p.87
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Helicobacter pylori Eradication Rate in Patients with Diabetes
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Yoo Ji-Yeon
Yu Yeong-Ji Cho Gu-Min Oh Hong-Won Oh Seung-Hyun Kim Tae-Ho Oh Jung-Hwan
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Abstract
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Background/Aims: The prevalence of diabetes mellitus is increasing. Little is known about the difference in Helicobacter pylori eradication rates between diabetic patients and non-diabetics. The aim of this study was to compare the eradication rate between diabetic and non-diabetic patients.
Materials and Methods: The medical records of patients who received a proton pump inhibitor (PPI)-based eradication therapy between 2012 and 2015 were retrospectively reviewed. All the patients underwent endoscopic biopsy to confirm H. pylori infection. Successful eradication was confirmed by using the 13C-urea breath test, biopsy, or rapid urease test, which was performed at least 4 weeks after the end of eradication therapy.
Results: A total of 1,402 patients were included. The eradication rate was 74.3% (1,041/1,402; 95% CI, 72.0¡76.5%). Excluding 151 patients who were confirmed to have no diabetes, 182 diabetic and 1,069 non-diabetic patients were compared. No significant difference (P=0.667) in eradication rate with PPI-amoxicillin-clarithromycin therapy was found between the diabetic (75.8%, 138/182; 95% CI, 69.6¡82.0%) and non-diabetic groups (74.0%, 791/1,069; 95% CI, 71.4¡76.6%). Peptic ulcer was much more common in the diabetic group than in the non-diabetic group (67.0% vs. 57.9%, P=0.038).
Conclusions: The H. pylori eradication rate with PPI-based triple therapy in the diabetic patients was probably not different from that in non-diabetic patients.
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KEYWORD
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Diabetes mellitus, Helicobacter pylori, Prevalence, Retrospective studies
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